{"id":23,"date":"2024-04-22T14:58:44","date_gmt":"2024-04-22T14:58:44","guid":{"rendered":"https:\/\/fund.southampton.ac.uk\/?p=23"},"modified":"2024-04-24T13:11:55","modified_gmt":"2024-04-24T13:11:55","slug":"davids-story-immunotherapy","status":"publish","type":"case-study","link":"https:\/\/fund.southampton.ac.uk\/innovation\/case-study\/davids-story-immunotherapy\/","title":{"rendered":"David’s story: How immunotherapy is giving people time and hope"},"content":{"rendered":"\n

David Coggon is an Emeritus Professor in the School of Medicine at the University of Southampton. After feeling unwell for a number of months, David was diagnosed with advanced kidney cancer. His health deteriorated very quickly and his prognosis was poor; at one point, it seemed he only had days to live and had begun the task of giving away his possessions.<\/strong><\/p>\n\n\n\n

When David started his PhD in Southampton back in 1980 he would never have guessed that one day he would be on the receiving end of innovative new treatments developed and delivered at the very same institution. Thankfully, after successful immunotherapy at University Hospital Southampton, David is now feeling fit and well, and able to enjoy his life once more.<\/p>\n\n\n\n

David, a father of five who lives in Hampshire with his wife, first experienced symptoms around eighteen months before he was diagnosed with kidney cancer. He recalls feeling unusually tired, even after sleeping all night, and falling asleep again straight after breakfast. This was completely out of character for him.<\/p>\n\n\n\n

David says, \u201cI was feeling generally run down with a persistent cough, but put it down to a series of respiratory infections and then long-term effects of COVID. I was also losing weight, which was pleasing at first, but in retrospect was happening far too easily.\u201d<\/p>\n\n\n\n

However, when he then passed blood in his urine, he knew that it was time to consult his GP. He was referred for various tests and diagnosed with kidney cancer that had spread to his lung. At this point, he was seriously unwell, with severe anaemia, and needing to sit down and rest after walking up one flight of stairs.  <\/p>\n\n\n\n

\u201cBy the time I got the diagnosis, I was so ill that I wasn\u2019t surprised. All I wanted to do was go home. I didn\u2019t want to die in hospital,\u201d David says.<\/p>\n\n\n\n

An immediate response through immunotherapy<\/h2>\n\n\n\n

David was referred to the oncology team but did not want to spend precious time on unpleasant treatments that would have little benefit. He sought informal advice from his friend, Peter Johnson, Professor of Medical Oncology. Peter\u2019s work has been critical in advancing cancer immunology, and he is the Cancer Mission Chair for the UK government, as well as a clinical researcher here in Southampton. Also, he had successfully treated David\u2019s wife when she suffered with a rare cancer, some 20 years previously.<\/p>\n\n\n\n

\u201cPeter was encouraging, explaining that treatment of kidney cancer had advanced significantly in recent years,\u201d David says, \u201cand he convinced me that it was worth giving it a go.\u201d <\/p>\n\n\n\n

David was under the care of Dr Matthew Wheater, who advised that he should have immunotherapy, with two drugs, Ipilimumab and Nivolumab. These drugs are given by intravenous infusion, and act by increasing the activity of the body\u2019s own immune system in recognising and killing cancer cells. The response was almost immediate.<\/p>\n\n\n\n

\u201cBy the time we had the results of the biopsy to confirm my suitability for treatment, my health was so bad that I truly didn\u2019t think I would make it through the weekend. I had lost 25kg in weight, including 5kg in the past three weeks. Thankfully, Matthew told me that I would be able to start my treatment the very next day.<\/p>\n\n\n\n

\u201cI started to feel better within four days,\u201d David says. \u201cI had a tingly feeling in my body, as though something was happening. I dared to hope this was a positive response and, thankfully, it was. My cough disappeared. I had energy. And I wanted to eat again.\u201d<\/p>\n\n\n\n

David\u2019s tumours were shrinking and he is now able to enjoy a quality of life that he couldn\u2019t have imagined before the treatment. Through immunotherapy, he has been given the gift of time. <\/p>\n\n\n\n

\u201cOver the past 12 months, I\u2019ve gone back to living my normal life. In fact, I feel better than I have done in years!\u201d David says. \u201cI\u2019m able to do heavy jobs in the garden; I did all the hedge cutting that I couldn\u2019t do last year. I\u2019ve decorated three rooms in our house. I\u2019m back enjoying long walks with my wife. And we have been on holiday in France with our camper van.\u201d<\/p>\n\n\n\n

The incredible evolution of cancer treatment<\/h2>\n\n\n\n

David’s wife suffered from cancer a number of years ago, and he saw the impact of her treatment first-hand. She is now, thankfully, fit and well, but the treatment she underwent was very aggressive. She was given chemotherapy and radiotherapy, which can cause patients to feel sick, lose their hair, and generally feel very weak and tired.<\/p>\n\n\n\n

\u201cCancer treatment is evolving,\u201d David says. \u201cMy wife\u2019s treatment was extremely unpleasant. My immunotherapy is nothing like that. I drive myself to and from the hospital, and I know I\u2019ll feel good afterwards.\u201d<\/p>\n\n\n\n

The future of medicine<\/h2>\n\n\n\n

David has enjoyed a rewarding and successful career in medicine. He has advised the government on topics ranging from regulation of pesticides to health effects of outdoor air pollution, toxicity of foods, compensation for occupational diseases, and the safety of mobile phone technology. Throughout his career he has been passionate about translating scientific evidence into policies that benefit the global population.<\/p>\n\n\n\n

\u201cMedical research is so important. We don\u2019t do it to invent a drug, but to change people\u2019s lives, just as it has for me,\u201d David says. \u201cIt\u2019s exciting to think about what the future of medical research holds; the best ideas have always come from thinking outside of the box. It will be particularly fascinating to see where applications of artificial intelligence in the medical sphere can take us. Engineering is now being applied to health and delivering major improvements, for example it is used to manage diabetes, and in the design of prosthetics. There are some incredible advances.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

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